Maternal Eating Disorders, Body Mass Index, and Offspring Psychiatric Diagnoses

Maternal nutrition is essential in fetal development; thus, disordered eating may influence this process and contribute to the development of offspring psychiatric disorders. To investigate the association of maternal eating disorders and prepregnancy body mass index (BMI) with offspring psychiatric...

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Bibliographic Details
Published in:JAMA network open 2024-10, Vol.7 (10), p.e2440517
Main Authors: Nilsson, Ida A K, Ozsvar, Judit, Gissler, Mika, Lavebratt, Catharina
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Cohort analysis
Cohort Studies
Eating disorders
Feeding and Eating Disorders - epidemiology
Female
Finland - epidemiology
Humans
Infant, Newborn
Male
Mental disorders
Mental Disorders - epidemiology
Obesity
Online Only
Original Investigation
Overweight
Pregnancy
Pregnancy Complications - epidemiology
Prenatal Exposure Delayed Effects - epidemiology
Proportional Hazards Models
Psychiatry
Registries
Risk Factors
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Summary:Maternal nutrition is essential in fetal development; thus, disordered eating may influence this process and contribute to the development of offspring psychiatric disorders. To investigate the association of maternal eating disorders and prepregnancy body mass index (BMI) with offspring psychiatric diagnoses. This population-based cohort study used Finnish national registers to assess all live births from January 1, 2004, through December 31, 2014, with follow-up until December 31, 2021. The data analyses were conducted from September 1, 2023, to September 30, 2024. Maternal eating disorder and prepregnancy BMI. Primary outcomes were 9 neurodevelopmental and psychiatric offspring diagnoses. Cox proportional hazards modeling adjusted for potential risk factors in the development of the outcome disorders was applied in 2 models. Secondary analyses were stratified for adverse birth outcomes (prematurity, small size for gestational age, and low Apgar score) or comorbid offspring eating disorders. Categories of BMI (calculated as weight in kilograms divided by height in meters squared) included underweight (BMI
ISSN:2574-3805
2574-3805
DOI:10.1001/jamanetworkopen.2024.40517