New Building Blocks for Peptide Analogue Synthesis: Reduced Diaza-β3-Dipeptides

Abstract Reduction of N-protected aza-β 3 -amino esters and oxidation of the alcohols afford aza-β 3 -amino aldehydes. Condensation of unprotected aza-β 3 -amino esters to the resultant aldehydes leads to hydrazones, which have been converted by reduction to useful synthetic building blocks for soli...

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Bibliographic Details
Published in:Synlett 2005-10, Vol.2005 (17), p.2591-2594
Main Authors: Busnel, Olivier, Baudy-Floc’h, Michèle
Format: Article
Language:English
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Summary:Abstract Reduction of N-protected aza-β 3 -amino esters and oxidation of the alcohols afford aza-β 3 -amino aldehydes. Condensation of unprotected aza-β 3 -amino esters to the resultant aldehydes leads to hydrazones, which have been converted by reduction to useful synthetic building blocks for solid-phase synthesis of new peptidomimetics.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-917100