A Putative Ca2+and Calmodulin-Dependent Protein Kinase Required for Bacterial and Fungal Symbioses

Legumes can enter into symbiotic relationships with both nitrogen-fixing bacteria (rhizobia) and mycorrhizal fungi. Nodulation by rhizobia results from a signal transduction pathway induced in legume roots by rhizobial Nod factors. DMI3, a Medicago truncatula gene that acts immediately downstream of...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2004-02, Vol.303 (5662), p.1361-1364
Main Authors: Lévy, Julien, Bres, Cécile, Geurts, René, Chalhoub, Boulos, Kulikova, Olga, Duc, Gérard, Journet, Etienne-Pascal, Ané, Jean-Michel, Lauber, Emmanuelle, Bisseling, Ton, Dénarié, Jean, Rosenberg, Charles, Debellé, Frédéric
Format: Article
Language:English
Subjects:
Alleles
Amino Acid Sequence
Biological and medical sciences
Calcium
Calcium - metabolism
Calcium Signaling
calcium spiking
Calcium-Calmodulin-Dependent Protein Kinases - chemistry
Calcium-Calmodulin-Dependent Protein Kinases - genetics
Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Calmodulin - metabolism
Cellular Biology
Chromosomes, Artificial, Bacterial
Cloning, Molecular
EF Hand Motifs
Expressed Sequence Tags
Fundamental and applied biological sciences. Psychology
gene
Gene Expression Regulation, Plant
Genes, Plant
Infections
Legumes
Life Sciences
Lipopolysaccharides - metabolism
Medicago - enzymology
Medicago - genetics
Medicago - microbiology
medicago-truncatula
Molecular Sequence Data
mutants
Mutation
Mycorrhizae - physiology
nod factor transduction
Nodulation
Nodules
Parasitism and symbiosis
perception
Pisum sativum - enzymology
Pisum sativum - genetics
Pisum sativum - microbiology
Plant physiology and development
Plant roots
Plant Roots - enzymology
Plant Roots - microbiology
Plants
Protein Structure, Tertiary
Proteins
recognition
responses
Rhizobium - genetics
signal
Sinorhizobium meliloti - physiology
Symbiosis
Transformation, Genetic
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Summary:Legumes can enter into symbiotic relationships with both nitrogen-fixing bacteria (rhizobia) and mycorrhizal fungi. Nodulation by rhizobia results from a signal transduction pathway induced in legume roots by rhizobial Nod factors. DMI3, a Medicago truncatula gene that acts immediately downstream of calcium spiking in this signaling pathway and is required for both nodulation and mycorrhizal infection, has high sequence similarity to genes encoding calcium and calmodulin-dependent protein kinases (CCaMKs). This indicates that calcium spiking is likely an essential component of the signaling cascade leading to nodule development and mycorrhizal infection, and sheds light on the biological role of plant CCaMKs.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1093038