Exercise training improves liver steatosis in mice

Non-alcoholic fatty liver disease (NAFLD) is rapidly turning into the most common liver disorder worldwide. One of the strategies that has been shown to effectively improve NAFLD is regular exercise, which seems to lower steatosis partly independent of weight loss. However, limited data are availabl...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition & metabolism 2015-08, Vol.12 (1), p.29-29, Article 29
Main Authors: Alex, Sheril, Boss, Andreas, Heerschap, Arend, Kersten, Sander
Format: Article
Language:English
Subjects:
Care and treatment
Chair Nutrition Metabolism and Genomics
Choline
Dextrose
Fatty acids
Glucose
Glycogen
HNE Nutrition, Metabolism and Genomics
HNE Voeding, Metabolisme en Genomics
Liver
Liver diseases
Metabolism
Nutrition
Nutrition, Metabolism and Genomics
Obesity
Physiological aspects
Triglycerides
VLAG
Voeding, Metabolisme en Genomica
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c579t-a66041eb9c2b2fe1526f048b74de3aafcb760da5b8685f631af08554270fc85a3
cites cdi_FETCH-LOGICAL-c579t-a66041eb9c2b2fe1526f048b74de3aafcb760da5b8685f631af08554270fc85a3
container_end_page 29
container_issue 1
container_start_page 29
container_title Nutrition & metabolism
container_volume 12
creator Alex, Sheril
Boss, Andreas
Heerschap, Arend
Kersten, Sander
description Non-alcoholic fatty liver disease (NAFLD) is rapidly turning into the most common liver disorder worldwide. One of the strategies that has been shown to effectively improve NAFLD is regular exercise, which seems to lower steatosis partly independent of weight loss. However, limited data are available about the mechanisms involved. The aim of the present study was to identify the mechanisms underlying the effect of regular exercise on liver steatosis. Non-obese male mice were rendered steatotic by feeding a sucrose-enriched choline-deficient diet. They were then subjected to daily treadmill running for three weeks, whereas the control mice remained sedentary. Compared to the untrained mice, trained mice showed similar adipose tissue mass but had significantly reduced size of lipid droplets in the liver coupled with a reduction in liver triglyceride content (~30 %, P 
doi_str_mv 10.1186/s12986-015-0026-1
format article
fullrecord <record><control><sourceid>gale_wagen</sourceid><recordid>TN_cdi_wageningen_narcis_oai_library_wur_nl_wurpubs_496587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A541532805</galeid><sourcerecordid>A541532805</sourcerecordid><originalsourceid>FETCH-LOGICAL-c579t-a66041eb9c2b2fe1526f048b74de3aafcb760da5b8685f631af08554270fc85a3</originalsourceid><addsrcrecordid>eNptkl1rFDEYhQdRbK3-AG9kwBu9mJpk8jVeFEqpWigIfly_ZLJvxpTZZE1mtvXfm3Hr0hXJRULynJPkcKrqJSWnlGr5LlPWadkQKhpCmGzoo-qYKt42iijx-MH6qHqW8w0hbcs78rQ6YpIJKqU6rtjlHSbrM9ZTMj74MNR-vUlxi7ke_RZTnSc0U8w-1z7Ua2_xefXEmTHji_v5pPr-4fLbxafm-vPHq4vz68YK1U2NkZJwin1nWc8cUsGkI1z3iq-wNcbZXkmyMqLXUgsnW2oc0UJwpoizWpj2pHq_8701Ay4vwwDBLI-FaDyMvk8m_YLbOUEYl2kz9xl4J4VWRXy2E5fNNa4shvK_ETbJrxfRYnB4EvwPGOIWuGCK6q4YvLk3SPHnjHmCtc8Wx9EEjHMGqkrikkgiCvr6H_QmzimUbAqliVSclOj31GBGBB9cLPfaxRTOBaeiZfqP1-l_qDJWWLKPAZ0v-weCtweCwkx4Nw1mzhmuvn45ZOmOtSnmnNDt86AElkbBrlFQGgVLo4AWzauHQe4VfyvU_gboQ8WA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780674000</pqid></control><display><type>article</type><title>Exercise training improves liver steatosis in mice</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Alex, Sheril ; Boss, Andreas ; Heerschap, Arend ; Kersten, Sander</creator><creatorcontrib>Alex, Sheril ; Boss, Andreas ; Heerschap, Arend ; Kersten, Sander</creatorcontrib><description>Non-alcoholic fatty liver disease (NAFLD) is rapidly turning into the most common liver disorder worldwide. One of the strategies that has been shown to effectively improve NAFLD is regular exercise, which seems to lower steatosis partly independent of weight loss. However, limited data are available about the mechanisms involved. The aim of the present study was to identify the mechanisms underlying the effect of regular exercise on liver steatosis. Non-obese male mice were rendered steatotic by feeding a sucrose-enriched choline-deficient diet. They were then subjected to daily treadmill running for three weeks, whereas the control mice remained sedentary. Compared to the untrained mice, trained mice showed similar adipose tissue mass but had significantly reduced size of lipid droplets in the liver coupled with a reduction in liver triglyceride content (~30 %, P &lt; 0.05). Levels of various plasma lipid parameters and plasma glucose were similar between the trained and untrained mice, whereas levels of hepatic glycogen were significantly higher in the trained mice. Hepatic triglyceride secretion rate and de novo lipogenesis were unchanged between the two sets of mice, as were indicators of lipolysis and autophagy. Finally, whole genome expression profiling indicated a mild stimulatory effect of exercise training on PPARα-mediated regulation of oxidative metabolism, including fatty acid oxidation. Taken together, our study suggests that the lowering of hepatic steatosis by repeated exercise is likely due to activation of fuel oxidation pathways in liver.</description><identifier>ISSN: 1743-7075</identifier><identifier>EISSN: 1743-7075</identifier><identifier>DOI: 10.1186/s12986-015-0026-1</identifier><identifier>PMID: 26251667</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Care and treatment ; Chair Nutrition Metabolism and Genomics ; Choline ; Dextrose ; Fatty acids ; Glucose ; Glycogen ; HNE Nutrition, Metabolism and Genomics ; HNE Voeding, Metabolisme en Genomics ; Liver ; Liver diseases ; Metabolism ; Nutrition ; Nutrition, Metabolism and Genomics ; Obesity ; Physiological aspects ; Triglycerides ; VLAG ; Voeding, Metabolisme en Genomica</subject><ispartof>Nutrition &amp; metabolism, 2015-08, Vol.12 (1), p.29-29, Article 29</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Alex et al. 2015</rights><rights>Wageningen University &amp; Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c579t-a66041eb9c2b2fe1526f048b74de3aafcb760da5b8685f631af08554270fc85a3</citedby><cites>FETCH-LOGICAL-c579t-a66041eb9c2b2fe1526f048b74de3aafcb760da5b8685f631af08554270fc85a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527189/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1780674000?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26251667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alex, Sheril</creatorcontrib><creatorcontrib>Boss, Andreas</creatorcontrib><creatorcontrib>Heerschap, Arend</creatorcontrib><creatorcontrib>Kersten, Sander</creatorcontrib><title>Exercise training improves liver steatosis in mice</title><title>Nutrition &amp; metabolism</title><addtitle>Nutr Metab (Lond)</addtitle><description>Non-alcoholic fatty liver disease (NAFLD) is rapidly turning into the most common liver disorder worldwide. One of the strategies that has been shown to effectively improve NAFLD is regular exercise, which seems to lower steatosis partly independent of weight loss. However, limited data are available about the mechanisms involved. The aim of the present study was to identify the mechanisms underlying the effect of regular exercise on liver steatosis. Non-obese male mice were rendered steatotic by feeding a sucrose-enriched choline-deficient diet. They were then subjected to daily treadmill running for three weeks, whereas the control mice remained sedentary. Compared to the untrained mice, trained mice showed similar adipose tissue mass but had significantly reduced size of lipid droplets in the liver coupled with a reduction in liver triglyceride content (~30 %, P &lt; 0.05). Levels of various plasma lipid parameters and plasma glucose were similar between the trained and untrained mice, whereas levels of hepatic glycogen were significantly higher in the trained mice. Hepatic triglyceride secretion rate and de novo lipogenesis were unchanged between the two sets of mice, as were indicators of lipolysis and autophagy. Finally, whole genome expression profiling indicated a mild stimulatory effect of exercise training on PPARα-mediated regulation of oxidative metabolism, including fatty acid oxidation. Taken together, our study suggests that the lowering of hepatic steatosis by repeated exercise is likely due to activation of fuel oxidation pathways in liver.</description><subject>Care and treatment</subject><subject>Chair Nutrition Metabolism and Genomics</subject><subject>Choline</subject><subject>Dextrose</subject><subject>Fatty acids</subject><subject>Glucose</subject><subject>Glycogen</subject><subject>HNE Nutrition, Metabolism and Genomics</subject><subject>HNE Voeding, Metabolisme en Genomics</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Metabolism</subject><subject>Nutrition</subject><subject>Nutrition, Metabolism and Genomics</subject><subject>Obesity</subject><subject>Physiological aspects</subject><subject>Triglycerides</subject><subject>VLAG</subject><subject>Voeding, Metabolisme en Genomica</subject><issn>1743-7075</issn><issn>1743-7075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptkl1rFDEYhQdRbK3-AG9kwBu9mJpk8jVeFEqpWigIfly_ZLJvxpTZZE1mtvXfm3Hr0hXJRULynJPkcKrqJSWnlGr5LlPWadkQKhpCmGzoo-qYKt42iijx-MH6qHqW8w0hbcs78rQ6YpIJKqU6rtjlHSbrM9ZTMj74MNR-vUlxi7ke_RZTnSc0U8w-1z7Ua2_xefXEmTHji_v5pPr-4fLbxafm-vPHq4vz68YK1U2NkZJwin1nWc8cUsGkI1z3iq-wNcbZXkmyMqLXUgsnW2oc0UJwpoizWpj2pHq_8701Ay4vwwDBLI-FaDyMvk8m_YLbOUEYl2kz9xl4J4VWRXy2E5fNNa4shvK_ETbJrxfRYnB4EvwPGOIWuGCK6q4YvLk3SPHnjHmCtc8Wx9EEjHMGqkrikkgiCvr6H_QmzimUbAqliVSclOj31GBGBB9cLPfaxRTOBaeiZfqP1-l_qDJWWLKPAZ0v-weCtweCwkx4Nw1mzhmuvn45ZOmOtSnmnNDt86AElkbBrlFQGgVLo4AWzauHQe4VfyvU_gboQ8WA</recordid><startdate>20150807</startdate><enddate>20150807</enddate><creator>Alex, Sheril</creator><creator>Boss, Andreas</creator><creator>Heerschap, Arend</creator><creator>Kersten, Sander</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>QVL</scope></search><sort><creationdate>20150807</creationdate><title>Exercise training improves liver steatosis in mice</title><author>Alex, Sheril ; Boss, Andreas ; Heerschap, Arend ; Kersten, Sander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c579t-a66041eb9c2b2fe1526f048b74de3aafcb760da5b8685f631af08554270fc85a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Care and treatment</topic><topic>Chair Nutrition Metabolism and Genomics</topic><topic>Choline</topic><topic>Dextrose</topic><topic>Fatty acids</topic><topic>Glucose</topic><topic>Glycogen</topic><topic>HNE Nutrition, Metabolism and Genomics</topic><topic>HNE Voeding, Metabolisme en Genomics</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Metabolism</topic><topic>Nutrition</topic><topic>Nutrition, Metabolism and Genomics</topic><topic>Obesity</topic><topic>Physiological aspects</topic><topic>Triglycerides</topic><topic>VLAG</topic><topic>Voeding, Metabolisme en Genomica</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alex, Sheril</creatorcontrib><creatorcontrib>Boss, Andreas</creatorcontrib><creatorcontrib>Heerschap, Arend</creatorcontrib><creatorcontrib>Kersten, Sander</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>NARCIS:Publications</collection><jtitle>Nutrition &amp; metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alex, Sheril</au><au>Boss, Andreas</au><au>Heerschap, Arend</au><au>Kersten, Sander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise training improves liver steatosis in mice</atitle><jtitle>Nutrition &amp; metabolism</jtitle><addtitle>Nutr Metab (Lond)</addtitle><date>2015-08-07</date><risdate>2015</risdate><volume>12</volume><issue>1</issue><spage>29</spage><epage>29</epage><pages>29-29</pages><artnum>29</artnum><issn>1743-7075</issn><eissn>1743-7075</eissn><abstract>Non-alcoholic fatty liver disease (NAFLD) is rapidly turning into the most common liver disorder worldwide. One of the strategies that has been shown to effectively improve NAFLD is regular exercise, which seems to lower steatosis partly independent of weight loss. However, limited data are available about the mechanisms involved. The aim of the present study was to identify the mechanisms underlying the effect of regular exercise on liver steatosis. Non-obese male mice were rendered steatotic by feeding a sucrose-enriched choline-deficient diet. They were then subjected to daily treadmill running for three weeks, whereas the control mice remained sedentary. Compared to the untrained mice, trained mice showed similar adipose tissue mass but had significantly reduced size of lipid droplets in the liver coupled with a reduction in liver triglyceride content (~30 %, P &lt; 0.05). Levels of various plasma lipid parameters and plasma glucose were similar between the trained and untrained mice, whereas levels of hepatic glycogen were significantly higher in the trained mice. Hepatic triglyceride secretion rate and de novo lipogenesis were unchanged between the two sets of mice, as were indicators of lipolysis and autophagy. Finally, whole genome expression profiling indicated a mild stimulatory effect of exercise training on PPARα-mediated regulation of oxidative metabolism, including fatty acid oxidation. Taken together, our study suggests that the lowering of hepatic steatosis by repeated exercise is likely due to activation of fuel oxidation pathways in liver.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26251667</pmid><doi>10.1186/s12986-015-0026-1</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1743-7075
ispartof Nutrition & metabolism, 2015-08, Vol.12 (1), p.29-29, Article 29
issn 1743-7075
1743-7075
language eng
recordid cdi_wageningen_narcis_oai_library_wur_nl_wurpubs_496587
source Publicly Available Content Database; PubMed Central
subjects Care and treatment
Chair Nutrition Metabolism and Genomics
Choline
Dextrose
Fatty acids
Glucose
Glycogen
HNE Nutrition, Metabolism and Genomics
HNE Voeding, Metabolisme en Genomics
Liver
Liver diseases
Metabolism
Nutrition
Nutrition, Metabolism and Genomics
Obesity
Physiological aspects
Triglycerides
VLAG
Voeding, Metabolisme en Genomica
title Exercise training improves liver steatosis in mice
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T22%3A13%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_wagen&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exercise%20training%20improves%20liver%20steatosis%20in%20mice&rft.jtitle=Nutrition%20&%20metabolism&rft.au=Alex,%20Sheril&rft.date=2015-08-07&rft.volume=12&rft.issue=1&rft.spage=29&rft.epage=29&rft.pages=29-29&rft.artnum=29&rft.issn=1743-7075&rft.eissn=1743-7075&rft_id=info:doi/10.1186/s12986-015-0026-1&rft_dat=%3Cgale_wagen%3EA541532805%3C/gale_wagen%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c579t-a66041eb9c2b2fe1526f048b74de3aafcb760da5b8685f631af08554270fc85a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1780674000&rft_id=info:pmid/26251667&rft_galeid=A541532805&rfr_iscdi=true