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Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease
Prevention of coronary heart disease (CHD) in high-risk subjects. To investigate the associations of dietary intake of alpha-linolenic acid (ALA) and linoleic acid (LA) as assessed by food frequency questionnaire and in the plasma cholesteryl ester (CE), with CHD risk factors. Baseline data of a dou...
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| Published in: | European journal of clinical nutrition 2000-12, Vol.54 (12), p.865-871 |
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| container_title | European journal of clinical nutrition |
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| creator | BEMELMANS, W. J. E MUSKIET, F. A. J FESKENS, E. J. M DE VRIES, J. H. M BROER, J MAY, J. F MEYBOOM-DE JONG, B |
| description | Prevention of coronary heart disease (CHD) in high-risk subjects.
To investigate the associations of dietary intake of alpha-linolenic acid (ALA) and linoleic acid (LA) as assessed by food frequency questionnaire and in the plasma cholesteryl ester (CE), with CHD risk factors.
Baseline data of a double-blind, randomized placebo-controlled trial. Subjects have hypercholesterolemia (6.0-8.0 mmol/l) and at least two other CHD risk factors (n=266).
The reported dietary ALA and LA intakes and the LA/ALA ratio were associated with the contents in the CE (r=0.37, r=0.21, and r=0.42, respectively; P |
| doi_str_mv | 10.1038/sj.ejcn.1601102 |
| format | article |
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To investigate the associations of dietary intake of alpha-linolenic acid (ALA) and linoleic acid (LA) as assessed by food frequency questionnaire and in the plasma cholesteryl ester (CE), with CHD risk factors.
Baseline data of a double-blind, randomized placebo-controlled trial. Subjects have hypercholesterolemia (6.0-8.0 mmol/l) and at least two other CHD risk factors (n=266).
The reported dietary ALA and LA intakes and the LA/ALA ratio were associated with the contents in the CE (r=0.37, r=0.21, and r=0.42, respectively; P<0.01). In multivariate analysis, CE ALA was inversely associated with diastolic blood pressure (r=-0.13; P<0.05) and positively with serum triacylglycerol (r=0.13; P<0.05), and CE LA was inversely associated with serum triacylglycerol (r=-0.32; P<0.01). The CE LA/ALA ratio was strongly inversely associated with CE ALA (r=-0.95; P<0.01). In the lowest quintile of CE ALA, mean dietary intake was 0.4 energy % ALA (1.2 g/day), 8.4 energy % LA and an LA/ALA ratio of 21, and in the highest quintile 0.6 energy % ALA (1.7 g/day), 6.8 energy % LA and 12 (ratio). In the lowest quintile of CE ALA the diastolic blood pressure was 4 mm Hg lower (P trend<0.05), and the serum triacylglycerol 0.3 mmol/l higher (P trend NS) when compared with the top quintile.
In a CHD high-risk population with LA-rich background diet, these cross-sectional data suggest that replacing LA in the diet by ALA may decrease diastolic blood pressure, and may increase serum triacylglycerol concentration.]]></description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1601102</identifier><identifier>PMID: 11114683</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Acids ; Adult ; Afdeling Humane voeding ; Aged ; alpha-Linolenic Acid - blood ; alpha-Linolenic Acid - pharmacology ; Biological and medical sciences ; Blindness ; Blood pressure ; Blood Pressure - drug effects ; Cardiovascular disease ; Cardiovascular diseases ; Cholesterol ; Cholesterol Esters - blood ; Cholesterol Esters - chemistry ; Clinical nutrition ; Clinical trials ; Coronary artery disease ; Coronary Disease - diet therapy ; Coronary Disease - etiology ; Coronary Disease - prevention & control ; Coronary heart disease ; Cross-Sectional Studies ; Design factors ; Diet ; Dietary Fats - pharmacology ; Dietary intake ; Diseases of the cardiovascular system ; Double-Blind Method ; Energy ; Female ; Food intake ; Health aspects ; Heart diseases ; Human Nutrition ; Human Nutrition & Health ; Human Nutrition (HNE) ; Humane Voeding ; Humane Voeding & Gezondheid ; Humans ; Hypercholesterolemia ; Hypercholesterolemia - complications ; Linoleic acid ; Linoleic Acid - adverse effects ; Linoleic Acid - blood ; Linoleic acids ; Linolenic acid ; Linolenic acids ; Male ; Margarine ; Medical sciences ; Middle Aged ; Multivariate analysis ; Nutrition ; Prevention ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Risk analysis ; Risk Factors ; Surveys and Questionnaires ; Triglycerides ; Triglycerides - analysis ; VLAG</subject><ispartof>European journal of clinical nutrition, 2000-12, Vol.54 (12), p.865-871</ispartof><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2000 Nature Publishing Group</rights><rights>Copyright Macmillan Journals Ltd. Dec 2000</rights><rights>Macmillan Publishers Limited 2000.</rights><rights>Wageningen University & Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-e8b3c2f65c79cb4f87411bd05ba8522aa0d7b04e09423ba69426b31234a1e7f83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=829360$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11114683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BEMELMANS, W. J. E</creatorcontrib><creatorcontrib>MUSKIET, F. A. J</creatorcontrib><creatorcontrib>FESKENS, E. J. M</creatorcontrib><creatorcontrib>DE VRIES, J. H. M</creatorcontrib><creatorcontrib>BROER, J</creatorcontrib><creatorcontrib>MAY, J. F</creatorcontrib><creatorcontrib>MEYBOOM-DE JONG, B</creatorcontrib><title>Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><description><![CDATA[Prevention of coronary heart disease (CHD) in high-risk subjects.
To investigate the associations of dietary intake of alpha-linolenic acid (ALA) and linoleic acid (LA) as assessed by food frequency questionnaire and in the plasma cholesteryl ester (CE), with CHD risk factors.
Baseline data of a double-blind, randomized placebo-controlled trial. Subjects have hypercholesterolemia (6.0-8.0 mmol/l) and at least two other CHD risk factors (n=266).
The reported dietary ALA and LA intakes and the LA/ALA ratio were associated with the contents in the CE (r=0.37, r=0.21, and r=0.42, respectively; P<0.01). In multivariate analysis, CE ALA was inversely associated with diastolic blood pressure (r=-0.13; P<0.05) and positively with serum triacylglycerol (r=0.13; P<0.05), and CE LA was inversely associated with serum triacylglycerol (r=-0.32; P<0.01). The CE LA/ALA ratio was strongly inversely associated with CE ALA (r=-0.95; P<0.01). In the lowest quintile of CE ALA, mean dietary intake was 0.4 energy % ALA (1.2 g/day), 8.4 energy % LA and an LA/ALA ratio of 21, and in the highest quintile 0.6 energy % ALA (1.7 g/day), 6.8 energy % LA and 12 (ratio). In the lowest quintile of CE ALA the diastolic blood pressure was 4 mm Hg lower (P trend<0.05), and the serum triacylglycerol 0.3 mmol/l higher (P trend NS) when compared with the top quintile.
In a CHD high-risk population with LA-rich background diet, these cross-sectional data suggest that replacing LA in the diet by ALA may decrease diastolic blood pressure, and may increase serum triacylglycerol concentration.]]></description><subject>Acids</subject><subject>Adult</subject><subject>Afdeling Humane voeding</subject><subject>Aged</subject><subject>alpha-Linolenic Acid - blood</subject><subject>alpha-Linolenic Acid - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blindness</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cholesterol</subject><subject>Cholesterol Esters - blood</subject><subject>Cholesterol Esters - chemistry</subject><subject>Clinical nutrition</subject><subject>Clinical trials</subject><subject>Coronary artery disease</subject><subject>Coronary Disease - diet therapy</subject><subject>Coronary Disease - etiology</subject><subject>Coronary Disease - prevention & control</subject><subject>Coronary heart disease</subject><subject>Cross-Sectional Studies</subject><subject>Design factors</subject><subject>Diet</subject><subject>Dietary Fats - pharmacology</subject><subject>Dietary intake</subject><subject>Diseases of the cardiovascular system</subject><subject>Double-Blind Method</subject><subject>Energy</subject><subject>Female</subject><subject>Food intake</subject><subject>Health aspects</subject><subject>Heart diseases</subject><subject>Human Nutrition</subject><subject>Human Nutrition & Health</subject><subject>Human Nutrition (HNE)</subject><subject>Humane Voeding</subject><subject>Humane Voeding & Gezondheid</subject><subject>Humans</subject><subject>Hypercholesterolemia</subject><subject>Hypercholesterolemia - complications</subject><subject>Linoleic acid</subject><subject>Linoleic Acid - adverse effects</subject><subject>Linoleic Acid - blood</subject><subject>Linoleic acids</subject><subject>Linolenic acid</subject><subject>Linolenic acids</subject><subject>Male</subject><subject>Margarine</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Nutrition</subject><subject>Prevention</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Triglycerides</subject><subject>Triglycerides - analysis</subject><subject>VLAG</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNp9kk2LFDEQhhtR3HX17E0ahfXUs_lO-jgsfsGCFz2H6nSykzGTjEk3g__etDOLq6wmkILK84aqyts0LzFaYUTVVdmu7NbEFRYIY0QeNeeYSdFxwdDj5hz1nHUUIXnWPCtli1C9lORpc4brYkLR88asS0nGw-RTLG1yLYT9BrrgYwo2etOC8WMLcWyPqbvMwU-bNvvyrXVgppRL61JuTcopQv7RbizkqR19sVDs8-aJg1Dsi1O8aL6-f_fl-mN38_nDp-v1TWe4EFNn1UANcYIb2ZuBOSUZxsOI-ACKEwKARjkgZlHPCB1A1CAGigllgK10il40_fHdA9zW2mM9dK3G-KITeB38kGtt-jBnHcMS9vNQtKA9R1X79qjd5_R9tmXSO1-MDQGiTXPRkjPVc6lkJS__TxImOVe4gm_-ArdpzrFOQBNRayeKIVqp1_-kcC84l3jprDtCtxCs9tGlKYOp_dkMIUXrfE2vca-wxAT1lV89wNc92p03Dwou7wnq74VpU1KYf9niT_DqCJqcSsnW6X32u2WsGOnFkrps9WJJfbJkVbw6NTgPOzv-5k8evDcnKAaCyxCXL7vjFOmpQPQn6Pfotg</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>BEMELMANS, W. 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J. E ; MUSKIET, F. A. J ; FESKENS, E. J. M ; DE VRIES, J. H. M ; BROER, J ; MAY, J. F ; MEYBOOM-DE JONG, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-e8b3c2f65c79cb4f87411bd05ba8522aa0d7b04e09423ba69426b31234a1e7f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Afdeling Humane voeding</topic><topic>Aged</topic><topic>alpha-Linolenic Acid - blood</topic><topic>alpha-Linolenic Acid - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blindness</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cholesterol</topic><topic>Cholesterol Esters - blood</topic><topic>Cholesterol Esters - chemistry</topic><topic>Clinical nutrition</topic><topic>Clinical trials</topic><topic>Coronary artery disease</topic><topic>Coronary Disease - diet therapy</topic><topic>Coronary Disease - etiology</topic><topic>Coronary Disease - prevention & control</topic><topic>Coronary heart disease</topic><topic>Cross-Sectional Studies</topic><topic>Design factors</topic><topic>Diet</topic><topic>Dietary Fats - pharmacology</topic><topic>Dietary intake</topic><topic>Diseases of the cardiovascular system</topic><topic>Double-Blind Method</topic><topic>Energy</topic><topic>Female</topic><topic>Food intake</topic><topic>Health aspects</topic><topic>Heart diseases</topic><topic>Human Nutrition</topic><topic>Human Nutrition & Health</topic><topic>Human Nutrition (HNE)</topic><topic>Humane Voeding</topic><topic>Humane Voeding & Gezondheid</topic><topic>Humans</topic><topic>Hypercholesterolemia</topic><topic>Hypercholesterolemia - complications</topic><topic>Linoleic acid</topic><topic>Linoleic Acid - adverse effects</topic><topic>Linoleic Acid - blood</topic><topic>Linoleic acids</topic><topic>Linolenic acid</topic><topic>Linolenic acids</topic><topic>Male</topic><topic>Margarine</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Nutrition</topic><topic>Prevention</topic><topic>Radiotherapy. 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F</creatorcontrib><creatorcontrib>MEYBOOM-DE JONG, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>NARCIS:Publications</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BEMELMANS, W. J. E</au><au>MUSKIET, F. A. J</au><au>FESKENS, E. J. M</au><au>DE VRIES, J. H. M</au><au>BROER, J</au><au>MAY, J. F</au><au>MEYBOOM-DE JONG, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease</atitle><jtitle>European journal of clinical nutrition</jtitle><addtitle>Eur J Clin Nutr</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>54</volume><issue>12</issue><spage>865</spage><epage>871</epage><pages>865-871</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract><![CDATA[Prevention of coronary heart disease (CHD) in high-risk subjects.
To investigate the associations of dietary intake of alpha-linolenic acid (ALA) and linoleic acid (LA) as assessed by food frequency questionnaire and in the plasma cholesteryl ester (CE), with CHD risk factors.
Baseline data of a double-blind, randomized placebo-controlled trial. Subjects have hypercholesterolemia (6.0-8.0 mmol/l) and at least two other CHD risk factors (n=266).
The reported dietary ALA and LA intakes and the LA/ALA ratio were associated with the contents in the CE (r=0.37, r=0.21, and r=0.42, respectively; P<0.01). In multivariate analysis, CE ALA was inversely associated with diastolic blood pressure (r=-0.13; P<0.05) and positively with serum triacylglycerol (r=0.13; P<0.05), and CE LA was inversely associated with serum triacylglycerol (r=-0.32; P<0.01). The CE LA/ALA ratio was strongly inversely associated with CE ALA (r=-0.95; P<0.01). In the lowest quintile of CE ALA, mean dietary intake was 0.4 energy % ALA (1.2 g/day), 8.4 energy % LA and an LA/ALA ratio of 21, and in the highest quintile 0.6 energy % ALA (1.7 g/day), 6.8 energy % LA and 12 (ratio). In the lowest quintile of CE ALA the diastolic blood pressure was 4 mm Hg lower (P trend<0.05), and the serum triacylglycerol 0.3 mmol/l higher (P trend NS) when compared with the top quintile.
In a CHD high-risk population with LA-rich background diet, these cross-sectional data suggest that replacing LA in the diet by ALA may decrease diastolic blood pressure, and may increase serum triacylglycerol concentration.]]></abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>11114683</pmid><doi>10.1038/sj.ejcn.1601102</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2000-12, Vol.54 (12), p.865-871 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_wageningen_narcis_oai_library_wur_nl_wurpubs_63950 |
| source | EZB Electronic Journals Library |
| subjects | Acids Adult Afdeling Humane voeding Aged alpha-Linolenic Acid - blood alpha-Linolenic Acid - pharmacology Biological and medical sciences Blindness Blood pressure Blood Pressure - drug effects Cardiovascular disease Cardiovascular diseases Cholesterol Cholesterol Esters - blood Cholesterol Esters - chemistry Clinical nutrition Clinical trials Coronary artery disease Coronary Disease - diet therapy Coronary Disease - etiology Coronary Disease - prevention & control Coronary heart disease Cross-Sectional Studies Design factors Diet Dietary Fats - pharmacology Dietary intake Diseases of the cardiovascular system Double-Blind Method Energy Female Food intake Health aspects Heart diseases Human Nutrition Human Nutrition & Health Human Nutrition (HNE) Humane Voeding Humane Voeding & Gezondheid Humans Hypercholesterolemia Hypercholesterolemia - complications Linoleic acid Linoleic Acid - adverse effects Linoleic Acid - blood Linoleic acids Linolenic acid Linolenic acids Male Margarine Medical sciences Middle Aged Multivariate analysis Nutrition Prevention Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Risk analysis Risk Factors Surveys and Questionnaires Triglycerides Triglycerides - analysis VLAG |
| title | Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease |
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