Paraben Content in Adjacent Normal-malignant Breast Tissues from Women with Breast Cancer

Accumulation of estrogenic compounds and other carcinogens in normal breast tissues contributes to unpredictable breast cancer incidence during adolescence and throughout life. To assess the role of parabens in this phenomenon, the paraben content of adjacent normal-malignant breast tissues is measu...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2019-12, Vol.32 (12), p.893-904
Main Authors: Mehdi Amin, Mohammad, Tabatabaeian, Maryam, Chavoshani, Afsane, Amjadi, Elham, Hashemi, Majid, Ebrahimpour, Karim, Klishadi, Roya, Khazaei, Sedigheh, Mansourian, Marjan
Format: Article
Language:English
Subjects:
Adult
Aged
Breast - cytology
Breast - pathology
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cross-Sectional Studies
Demography
Female
Humans
Malignant tissues
Middle Aged
Normal tissues
Paraben
Parabens - metabolism
Risk Factors
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Summary:Accumulation of estrogenic compounds and other carcinogens in normal breast tissues contributes to unpredictable breast cancer incidence during adolescence and throughout life. To assess the role of parabens in this phenomenon, the paraben content of adjacent normal-malignant breast tissues is measured in women with breast cancer living in Isfahan Province, Iran. Adjacent normal-malignant breast tissue samples were obtained from 53 subjects. The parabens including methyl-paraben (MePB), ethyl-paraben (EtPB), propyl-paraben (PrPB), and butylparaben (BuPB) were extracted from the sample supernatant and then subjected to gas chromatography analysis. Some risk factors for breast cancer were stimulated by parabens in adjacent malignant-normal breast tissues among young and middle-aged women with breast cancer. We observed a significant association for dose-response pattern of MePB [OR = 98.34 (11.43–185.2), P = 0.027] for both ER+ and PR+ women and MePB [OR = 164.3 (CI: 112.3–216.3), P < 0.001] for HER2+ women than women with negative receptors. The risk of 95-fold increase in MePB dose and 164-fold increase in ΣPBs dose were significant for women with hereditary breast cancer in first-degree relatives. These results may promote future epidemiology studies and strategies to improve women's lifestyle and consume paraben-free products.
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2019.112