Synthesis and antibacterial activities of N-[(1-aryl-3-phenyl-pyrazol-4-yl)methylene]-2-(halo-o-hydroxyphenyl)hydrazide derivatives

A series of novel N -[(1-aryl-3-phenyl-pyrazol-4-yl)methylene]-2-(halo- o -hydroxyphenyl)hydrazide derivatives was synthesized and the antibacterial activity of each of them was evaluated. The supposed reaction mechanism of acquiring compounds 3 a– 3 d is that catalytic activity is enhanced by the e...

Full description

Saved in:
Bibliographic Details
Published in:Chemical research in Chinese universities 2013-06, Vol.29 (3), p.449-453
Main Authors: Liu, Ya, Lu, Bo-wei, Lu, Jun-rui, Xin, Chun-wei, Li, Jian-fa, Mu, Jiang-bei, Bao, Xiu-rong
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of novel N -[(1-aryl-3-phenyl-pyrazol-4-yl)methylene]-2-(halo- o -hydroxyphenyl)hydrazide derivatives was synthesized and the antibacterial activity of each of them was evaluated. The supposed reaction mechanism of acquiring compounds 3 a– 3 d is that catalytic activity is enhanced by the electron-donating groups of the first phenyl ring while decreased by electron-withdrawing groups of that ring. The result of preliminary bioassay shows that the lowest minimal inhibitory concentration(MIC) of the title compounds against Escherichia coli is 2 μg/mL. MIC values against Monilia albican and Staphlococcus aureus are as low as 4 μg/mL. They will be a series of potential antibacterial compounds against fungi and gram-negative bacteria.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-013-2491-2