Sirolimus-eluting stents for treatment of drug-eluting versus bare-metal stents restenosis： 42-month clinical outcomes from a Chinese single center

Background Restenosis of bare-metal stents （BMS） and drug-eluting stents （DES） has been increasingly treated with sirolimus-eluting stents （SES）, but the long-term outcomes are unknown. Methods In our study, 388 consecutive patients （144 DES restenosis and 244 BMS restenosis） with 400 lesions （147 D...

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Bibliographic Details
Published in:Chinese medical journal 2012-10, Vol.125 (19), p.3398-3403
Main Authors: Yan, Rong-Qiang, Chen, Ji-Lin, Gao, Li-Jian, Yang, Yue-Jin, Li, Jian-Jun, Qiao, Shu-Bin, Xu, Bo, Yao, Min, Qin, Xue-Wen, Liu, Hai-Bo, Wu, Yong-Jian, Yuan, Jin-Qing, Chen, Jue, You, Shi-Jie, Dai, Jun, Gao, Run-Lin
Format: Article
Language:English
Subjects:
Aged
Coronary Angiography
Coronary Restenosis - chemically induced
Coronary Restenosis - diagnostic imaging
Coronary Restenosis - therapy
Drug-Eluting Stents - adverse effects
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Sirolimus - therapeutic use
Stents - adverse effects
中国
临床
再狭窄
治疗
洗脱
药物
西罗莫司
金属支架
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Summary:Background Restenosis of bare-metal stents （BMS） and drug-eluting stents （DES） has been increasingly treated with sirolimus-eluting stents （SES）, but the long-term outcomes are unknown. Methods In our study, 388 consecutive patients （144 DES restenosis and 244 BMS restenosis） with 400 lesions （147 DES restenosis and 253 BMS restenosis） treated with SES were included. The rates of target lesion revascularization （TLR） and major adverse cardiac events （MACE） at 42 months were analyzed. Results At the mean follow-up of 42 months, the rates of death （3.5% vs. 3.3%, P=1.000） and myocardial infarction （2.8% vs. 1.2%, P=0.431） in the DES group and BMS group were comparable. Compared with the BMS group, ischemia-driven TLR occurred with a higher frequency in the DES group （18.8% vs.10.7%, P=0.024）. This translated into an increased rate of MACE in the DES group （22.2% vs. 14.0%, P=0.034）. Stent thrombosis occurred with a similar frequency in both groups （2.8% vs. 1.6%, P=0.475）. Multivariate analysis showed that DES restenosis （OR=1.907, 95% Cl 1.108-3.285, P=0.020） and smoking （OR=2.069; 95% Cl 1.188-3.605; P=0.010） were independent predictors of MACE.
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.2012.19.007