Giant Magnetic Heat Induction of Magnesium‐Doped γ‐Fe2O3 Superparamagnetic Nanoparticles for Completely Killing Tumors

• Published in: Advanced materials (Weinheim) 2018-02, Vol.30 (6), p.n/a
• Main Authors: Jang, Jung‐tak, Lee, Jooyoung, Seon, Jiyun, Ju, Eric, Kim, Minkyu, Kim, Young Il, Kim, Min Gyu, Takemura, Yasushi, Arbab, Ali Syed, Kang, Keon Wook, Park, Ki Ho, Paek, Sun Ha, Bae, Seongtae
• Format: Article
• Language: English
• Subjects: cancer treatment; giant magnetic heat induction; intrinsic loss power; magnetic fluid hyperthermia; Mg‐doped γ‐Fe2O3 nanoparticles
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.201704362

Magnetic fluid hyperthermia has been recently considered as a Renaissance of cancer treatment modality due to its remarkably low side effects and high treatment efficacy compared to conventional chemotheraphy or radiotheraphy. However, insufficient AC induction heating power at a biological safe range of AC magnetic field (Happl·fappl < 3.0–5.0 × 109 A m−1 s−1), and highly required biocompatibility of superparamagnetic nanoparticle (SPNP) hyperthermia agents are still remained as critical challenges for successful clinical hyperthermia applications. Here, newly developed highly biocompatible magnesium shallow doped γ‐Fe2O3 (Mg0.13‐γFe2O3) SPNPs with exceptionally high intrinsic loss power (ILP) in a range of 14 nH m2 kg−1, which is an ≈100 times higher than that of commercial Fe3O4 (Feridex, ILP = 0.15 nH m2 kg−1) at Happl·fappl = 1.23 × 109 A m−1 s−1 are reported. The significantly enhanced heat induction characteristics of Mg0.13‐γFe2O3 are primarily due to the dramatically enhanced out‐of‐phase magnetic susceptibility and magnetically tailored AC/DC magnetic softness resulted from the systematically controlled Mg2+ cations distribution and concentrations in octahedral site Fe vacancies of γ‐Fe2O3 instead of well‐known Fe3O4 SPNPs. In vitro and in vivo magnetic hyperthermia studies using Mg0.13‐γFe2O3 nanofluids are conducted to estimate bioavailability and biofeasibility. Mg0.13‐γFe2O3 nanofluids show promising hyperthermia effects to completely kill the tumors. Magnesium‐doped γ‐Fe2O3 (Mg0.13‐γFe2O3) superparamagnetic nanoparticles with exceptionally high intrinsic loss power of 14 nH m2 kg−1, which is ≈100 times higher than that of commercial Fe3O4 at a physiologically safe range of AC magnetic field (Happl·fappl = 1.23 × 109 A m−1 s−1), are developed. The hyperthermia effect using Mg0.13‐γFe2O3 nanofluids is revealed to be promising for completely killing tumors.