Synthesis of Hexahydroindoles by Intramolecular C sp 3H Alkenylation: Application to the Synthesis of the Core of Aeruginosins

Give me five: Pd‐catalyzed intramolecular C sp 3H arylations have been successfully extended to alkenylations. This method shows remarkable selectivity and gives synthetically useful hexahydroindoles, as illustrated with the synthesis of the octahydroindole core of the aeruginosin family of natural...

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Published in:Angewandte Chemie International Edition 2012-10, Vol.51 (41), p.10399-10402
Main Authors: Sofack-Kreutzer, Julien, Martin, Nicolas, Renaudat, Alice, Jazzar, Rodolphe, Baudoin, Olivier
Format: Article
Language:English
Subjects:
CC coupling
CH activation
natural products
nitrogen heterocycles
palladium
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container_issue 41
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creator Sofack-Kreutzer, Julien
Martin, Nicolas
Renaudat, Alice
Jazzar, Rodolphe
Baudoin, Olivier
description Give me five: Pd‐catalyzed intramolecular C sp 3H arylations have been successfully extended to alkenylations. This method shows remarkable selectivity and gives synthetically useful hexahydroindoles, as illustrated with the synthesis of the octahydroindole core of the aeruginosin family of natural products (see picture).
doi_str_mv 10.1002/anie.201205403
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subjects CC coupling
CH activation
natural products
nitrogen heterocycles
palladium
title Synthesis of Hexahydroindoles by Intramolecular C sp 3H Alkenylation: Application to the Synthesis of the Core of Aeruginosins
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