Applicability of the Øie‐Tozer model to predict three types of distribution volume (Vd) in humans: Vd in central compartment, Vd at steady state, and Vd at beta phase

This study aimed to investigate the applicability of the Øie‐Tozer model to predict human distribution volume (Vd) in the central compartment (V1), Vd at steady state (Vdss), and Vd at beta phase (Vdβ) based on animal Vd. Twenty compounds that have a human V1/Vdss of 0.053–0.66 were selected from th...

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Bibliographic Details
Published in:Biopharmaceutics & Drug Disposition 2020-04, Vol.41 (4-5), p.151-165
Main Authors: Yahata, Masahiro, Ishii, Yuji, Nakagawa, Tetsuya, Watanabe, Takao, Miyawaki, Izuru
Format: Article
Language:English
Subjects:
Allometry
Animals
Chlorpromazine
Dogs
Humans
Intravenous administration
Macaca fascicularis
Male
Models, Biological
Pharmaceutical Preparations
Pharmaceutical Preparations - blood
Pharmaceutical Preparations - metabolism
Pharmacokinetics
Predictions
Rats, Sprague-Dawley
V1, Vdss, Vdβ
Valproic acid
Øie‐Tozer model
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