Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1

The protease beta‐site APP cleaving enzyme 1 (BACE1) has fundamental functions in the nervous system. Its inhibition is a major therapeutic approach in Alzheimer's disease, because BACE1 cleaves the amyloid precursor protein (APP), thereby catalyzing the first step in the generation of the path...

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Bibliographic Details

Published in:	The FASEB journal 2020-02, Vol.34 (2), p.2465-2482
Main Authors:	Rudan Njavro, Jasenka, Klotz, Jakob, Dislich, Bastian, Wanngren, Johanna, Shmueli, Merav D., Herber, Julia, Kuhn, Peer‐Hendrik, Kumar, Rohit, Koeglsperger, Thomas, Conrad, Marcus, Wurst, Wolfgang, Feederle, Regina, Vlachos, Andreas, Michalakis, Stylianos, Jedlicka, Peter, Müller, Stephan A., Lichtenthaler, Stefan F.
Format:	Article
Language:	English
Subjects:	gamma‐secretase inhibitory synapse retina secretase SILAC
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