Evidence that FcRn mediates the transplacental passage of maternal IgE in the form of IgG anti-IgE/IgE immune complexes

Summary Background The mechanism(s) responsible for acquisition of maternal antibody isotypes other than IgG are not fully understood. This uncertainty is a major reason underlying the continued controversy regarding whether cord blood (CB) IgE originates in the mother or fetus. Objective To investi...

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Bibliographic Details
Published in:Clinical and experimental allergy 2015-06, Vol.45 (6), p.1085-1098
Main Authors: Bundhoo, A., Paveglio, S., Rafti, E., Dhongade, A., Blumberg, R. S., Matson, A. P.
Format: Article
Language:English
Subjects:
Adult
allergy
Animals
Antibodies, Anti-Idiotypic - immunology
Antibodies, Anti-Idiotypic - metabolism
Antigen-Antibody Complex - immunology
Antigen-Antibody Complex - metabolism
Autoantibodies
Cell Line
cord blood
FcRn
Female
Fetal Blood - immunology
Histocompatibility Antigens Class I - metabolism
Humans
Hypersensitivity - immunology
Hypersensitivity - metabolism
IgG anti-IgE
immune complexes
Immune system
Immunoglobulin E - blood
Immunoglobulin E - immunology
Immunoglobulin E - metabolism
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunoglobulin G - metabolism
infant
Medical research
mother
Original
placenta
Placenta - immunology
Placenta - metabolism
Pregnancy
Protein Binding
Protein Transport
Receptors, Fc - metabolism
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