The genomic SELEX‐based method identifies 350 SigA‐specific promoters in Mycobacterium tuberculosis

The gene regulation in Mycobacterium tuberculosis by different sigma factors, including the principal sigma factor, sigmaA (SigA), is poorly understood. Here, we have developed a modified genomic systematic evolution of ligands by exponential enrichment (SELEX)‐Seq approach that identifies 350 new S...

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Bibliographic Details
Published in:The FEBS journal 2026-01, Vol.293 (2), p.514-531
Main Authors: Jaiswal, Ritu, Dutta, Subhajit, Mukherjee, Soumya, Hazra, Nilanjana, Saha, Sudipto, Mukhopadhyay, Jayanta
Format: Article
Language:English
Subjects:
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Base Sequence
Binding Sites
Deoxyribonucleic acid
DNA
Electrophoretic mobility
gel electrophoresis
Gene Expression Regulation, Bacterial
Gene regulation
Gene sequencing
genes
Genome, Bacterial
Genomics
Genomics - methods
high‐throughput nucleotide sequencing
intergenic DNA
Mycobacterium tuberculosis
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - metabolism
Nucleotide sequence
Open reading frames
promoter
Promoter Regions, Genetic
Promoters
Protein Binding
SELEX
SELEX Aptamer Technique - methods
Sigma factor
Sigma Factor - genetics
Sigma Factor - metabolism
sigma factors
systematic evolution of ligands by exponential enrichment
Tuberculosis
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