Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

Summary The immunogenicity of cancer cells is an emerging determinant of anti‐cancer immunotherapy. Beyond developing immunostimulatory regimens like dendritic cell‐based vaccines, immune‐checkpoint blockers, and adoptive T‐cell transfer, investigators are beginning to focus on the immunobiology of...

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Bibliographic Details
Published in:	Immunological reviews 2017-11, Vol.280 (1), p.126-148
Main Authors:	Garg, Abhishek D., Agostinis, Patrizia
Format:	Article
Language:	English
Subjects:	Alarmins - immunology Animals Antigen (tumor-associated) Antigens, Neoplasm - immunology Apoptosis Autoantigens - immunology autophagy bacteria Cancer Cancer immunotherapy Cell Death Chemokines Clinical aspects Damage patterns danger signaling Dendritic cells endoplasmic reticulum stress ferroptosis Humans Immune checkpoint Immunity Immunogenicity Immunology Immunomodulation Immunostimulation Immunosuppression Immunotherapy infection Interferon Lymphocytes T metabolites microbe‐associated molecular patterns Mimicry Molecular Mimicry Mortality Necroptosis Necrosis Neoplasms - immunology Nucleic acids oncolytic virus Pathogens pattern recognition receptors phagocytosis Pyroptosis T-Lymphocytes - immunology Toll‐like receptors “eat me”/“find me” signals
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