Activated platelets kill Staphylococcus aureus, but not Streptococcus pneumoniae—The role of FcγRIIa and platelet factor 4/heparinantibodies

Background Heparin induced thrombocytopenia (HIT) is likely a misdirected bacterial host defense mechanism. Platelet factor 4 (PF4) binds to polyanions on bacterial surfaces exposing neo‐epitopes to which HIT antibodies bind. Platelets are activated by the resulting immune complexes via FcγRIIA, rel...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2020-06, Vol.18 (6), p.1459-1468
Main Authors: Wolff, Martina, Handtke, Stefan, Palankar, Raghavendra, Wesche, Jan, Kohler, Thomas P., Kohler, Christian, Gruel, Yves, Hammerschmidt, Sven, Greinacher, Andreas
Format: Article
Language:English
Subjects:
Antibodies
Anticoagulants
Antigen-antibody complexes
aPF4/H antibodies
Bacteria
Blood Platelets
Epitopes
FcγRIIa
Flow cytometry
Heparin
Humans
PF4
Phosphatidylserine
Platelet Factor 4
Platelets
Polyanions
Receptors, IgG
Staphylococcus aureus
Streptococcus infections
Streptococcus pneumoniae
Thrombocytopenia
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