Abstract 14045: Frailty as Assessed by Gait Speed is Associated With Peripheral Endothelial Dysfunction in Older Patients With ST-segment Elevation Myocardial Infarction

• Published in: Circulation (New York, N.Y.) N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A14045-A14045
• Main Authors: Satou, Ryosuke, Matsuzawa, Yasushi, Akiyama, Eiichi, Suzuki, Hiroyuki, Kawashima, Chika, Konishi, Masaaki, Hashiba, Katsutaka, Maejima, Nobuhiko, Iwahashi, Noriaki, Hibi, Kiyoshi, Kosuge, Masami, Ebina, Toshiaki, Sumita, Shinichi, Kimura, Kazuo, Kimura, Yuuichiro
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539

IntroductionEndothelial dysfunction plays a pivotal role in the progression of atherosclerosis and subsequent cardiovascular events. In older patients, decreased gait speed is associated with worse cardiovascular outcomes. However, the association with endothelial dysfunction and gait speed in older patients with ST-segment elevation myocardial infarction (STEMI) remains unclear.HypothesisWe assessed the hypothesis that slow gait speed is associated with peripheral endothelial dysfunction in older patients with STEMI.MethodsA total of 353 patients with STEMI were enrolled and divided into younger (age < 65 years) and older (age ≥ 65 years) groups. We assessed peripheral endothelial function by reactive hyperemia peripheral arterial tonometry (RH-PAT) as RH-PAT index (RHI), and we defined endothelial dysfunction as RHI≤1.67. Gait speeds were measured by using a 200-m course before discharge.ResultsThe prevalence of endothelial dysfunction was significantly higher in older patients than in younger patients (n=85 (48.9%) versus n=51 (28.5%), p