Abstract 18251: Differential DNA Methylation in Coronary Artery Restenosis After Angioplasty

IntroductionCoronary artery in-stent restenosis (ISR) occurs in 20 to 30% of those who receive bare metal stents and 5 to 10% with drug eluted stents. Since known clinical and genetic risk factors do not explain all incidence aspects of ISR, the epigenetics field appears as a promising arena. Among...

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Published in:Circulation (New York, N.Y.) N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A18251-A18251
Main Authors: Lanas, Fernando, Ruedlinger, Jenny, Saavedra, Nicolas, Bobadilla, Braulio, Potthoff, Marcelo, Perez, Luis, Salazar, Luis
Format: Article
Language:English
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Summary:IntroductionCoronary artery in-stent restenosis (ISR) occurs in 20 to 30% of those who receive bare metal stents and 5 to 10% with drug eluted stents. Since known clinical and genetic risk factors do not explain all incidence aspects of ISR, the epigenetics field appears as a promising arena. Among epigenetic mechanisms, DNA methylation is the most studied and better understood, being linked to cardiovascular disease.HypothesisCertain cytosine-guanine dinucleotide (CpG) sites are differentially methylated in patients who develop ISR with respect to a control group.MethodsForty eight patients with coronary artery stenosis ≥ 50% in the angioplasty site were included as cases and 48 with
ISSN:0009-7322
1524-4539