Abstract 14594: Diagnostic Performance of Quantitative Flow Ratio in Diabetic and Non-Diabetic Patients

• Published in: Circulation (New York, N.Y.) N.Y.), 2018-11, Vol.138 (Suppl_1 Suppl 1), p.A14594-A14594
• Main Authors: Smit, Jeff M, El Mahdiui, Mohammed, van Rosendael, Alexander R, Jukema, J Wouter, Koning, Gerhard, Reiber, Johan H, Bax, Jeroen J, Scholte, Arthur J
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539

IntroductionQuantitative flow ratio (QFR) is a novel non-invasive technique to calculate fractional flow reserve (FFR), without hyperaemia induction or an invasive pressure-wire. The diagnostic performance of QFR was recently demonstrated to be reduced in the presence of coronary microvascular dysfunction (CMD). QFR has not yet been validated in diabetic patients, which are known to have an increased risk of CMD.HypothesisWe assessed the hypothesis that the diagnostic performance of QFR is reduced in diabetic patients.MethodsPatients who underwent invasive coronary angiography and subsequent invasive FFR measurement within 6 months were included. QFR was determined in all coronary arteries in which invasive FFR was performed, using a dedicated software package. Diagnostic accuracy and the area under the receiver operating characteristic (ROC) curve were determined for QFR, using FFR as the reference standard. QFR and invasive FFR values of ≤0.80 were considered significant.ResultsIn total, 320 coronary arteries from 66 (25.5%) diabetic and 193 (74.5%) non-diabetic patients were analysed. On a vessel-based analysis, diagnostic accuracy, sensitivity and specificity showed no significant difference between diabetic and non-diabetic patients, 87.8% (95% confidence interval (CI) 78.7%-94.0%) vs. 84.5% (95% CI 79.2%-88.8%) (P = 0.47), 70.8% (95% CI 48.9%-87.4%) vs. 68.7% (95% CI 56.2%-79.4%) (P = 0.72) and 94.8% (95% CI 85.6%-98.9%) vs. 90.6% (95% CI 85.3%-94.6%) (P = 0.24). Moreover, the area under the ROC curve was not significantly different between diabetic and non-diabetic patients, 0.91 (95% CI 0.84-0.99) vs. 0.93 (95% CI 0.89-0.96) (P = 0.74).ConclusionsIn our study, we showed a good diagnostic performance of QFR which was independent of the presence of diabetes.