Abstract 14756: Translesional Fractional Flow is Related to Plaque Components With Lipid Core in Coronary Artery Disease

• Published in: Circulation (New York, N.Y.) N.Y.), 2018-11, Vol.138 (Suppl_1 Suppl 1), p.A14756-A14756
• Main Authors: Jin, Uram, Jung, Jisung, Mintz, Gary S, Choi, So-Yeon
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539

IntroductionIt remains unclear whether atherosclerotic plaque structure or composition is related to translesional biomechanical stresses in coronary artery disease.HypothesisWe assessed the hypothesis that there would be a relationship between translesional pressure parameters and plaque characteristics with lipid core.MethodsFractional flow reserve (FFR), delta (Δ) FFR, and Δpressure were obtained by pressure wire during adenosine induced maximum hyperemic status. Lipid core burden index (LCBI) and maximum LCBI within 2mm (maxLCBI2mm) and tomographic anatomy were evaluated by near-infrared spectroscopy with intravascular ultrasound imaging catheter.ResultsA total of 57 patients were enrolled. Among the 57 eligible vessels with 66 target lesions, continuous pullback pressure measurements - necessary to obtain ΔFFR and Δpressure - were available in 45 lesions (36 patients). The minimal lumen area was positively related with FFR while it tended to be inversely related with ΔFFR. Plaque burden and lesion length were inversely related with FFR and positively related with ΔFFR. There was a negative correlation between FFR and maxLCBI2mm (r=-0.264, p=0.049) and a positive correlation between ΔFFR and maxLCBI2mm (r=0.299, p=0.049). ΔFFR of lesions with maxLCBI2mm ≥500 was higher than maxLCBI2mm