Abstract 10122: A Randomized Trial of Exercise versus Low-energy Meal Replacement Diet to Improve Cardiac Dysfunction in Working-Age Adults With Type 2 Diabetes

• Published in: Circulation (New York, N.Y.) N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A10122-A10122
• Main Authors: Gulsin, Gaurav S, Swarbrick, Daniel J, Athithan, Lavanya, Brady, Emer M, Henson, Joseph J, Baldry, Emma, Argyridou, Stavroula, Marsh, Anna-Marie, Squire, Gareth, Jaicim, Nishal B, Biglands, John, Yates, Thomas, Khunti, Kamlesh, Davies, Melanie J, McCann, Gerry
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.140.suppl_1.10122

IntroductionAdults with type 2 diabetes (T2DM) may already have diastolic dysfunction, a precursor to heart failure. Whether weight loss or exercise improve subclinical diastolic dysfunction in T2DM is not known.MethodsPhase 1) Case-control comparison of obese adults with T2DM and no CVD, with age- and sex-matched controls. Phase 2) Prospective, randomised, open-label blinded endpoint trial. Ninety obese T2DMs (age 50±7y, 59% male, BMI 37±6 kg/m2) and 39 controls (age 49±7y, 51% male, BMI 24±2 kg/m2) were recruited for Phase 1. In Phase 2, T2DMs were randomised 1:1:1 to a 12-week intervention with either1) routine care; 2) a low-energy (≈810 kCal/day) meal replacement diet; or 3) a supervised aerobic exercise programme. Bio-anthropometric profiling and cardiac MRI at baseline and 12-weeks were performedResultsClinical and MRI data pre- and post-intervention are shown in Table 1. Compared to controls, T2DMs had more concentric LV remodelling (p