Abstract 11452: Impacts of Urinary Angiotensinogen as a Biomarker for Monitoring the Clinical Status in Patients With Congestive Heart Failure

• Published in: Circulation (New York, N.Y.) N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A11452-A11452
• Main Authors: Yokoyama, Shota, Kawakami, Ryo, Miyake, Yuichi, Ishizawa, Makoto, Tsuji, Teppei, Ishikawa, Kaori, Murakami, Kazushi, Noma, Takahisa, Minamino, Tetsuo
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.140.suppl_1.11452

IntroductionHeart failure (HF) is a global health burden and requires substantial healthcare due to recurrent admissions. Therefore, developing a non-invasive biomarker that does not require blood sample is desirable to evaluate the HF status briefly and prevent readmissions. Urinary angiotensinogen (uAGT) has been identified as an indicator for intrarenal renin-angiotensin system activity, which may be augmented during renal congestion in HF patients.HypothesisWe assessed the hypothesis that uAGT would be a promising urine biomarker for monitoring the HF status.MethodsWe measured uAGT by ELISA and normalized with urine creatinine (uCr) at admission and discharge in 45 patients hospitalized due to congestive HF. We assessed the association between uAGT/uCr and patients’ clinical status and laboratory data including NT-proBNP.ResultsThe clinical status of 45 HF patients improved during hospitalization (NYHAadmission, 3.2 ± 0.09; discharge, 1.2 ± 0.08, p < 0.01). We found that both uAGT/uCr (admission, 136.8 ± 35.1 μg/g Cr; discharge, 51.9 ± 16.7 μg/g Cr, p < 0.01) and NT-proBNP (admission, 6817 ± 899 pg/mL; discharge, 1945 ± 452 pg/mL, p < 0.01) were significantly decreased along with the improvement of clinical status, whereas no significant difference was observed in the renal function and blood pressure between admission and discharge. Of note, uAGT/uCr levels were significantly correlated with NT-proBNP at admission and discharge. In addition, the changes in uAGT/uCr were also associated with those in NT-proBNP. We further found that 5 patients had a readmission due to congestive HF and uAGT/uCr and NT-proBNP were increased at readmission as well as those at admission.ConclusionsThis study indicated that the changes in uAGT/uCr were associated with the clinical status of HF patients, consistent with the changes in NT-proBNP. In conclusion, uAGT could be a non-invasive and promising urine biomarker for monitoring the clinical status of HF patients.