Abstract 13058: Impact of Cied Infection: A Clinical and Economic Analysis of the Wrap-It Study

• Published in: Circulation (New York, N.Y.) N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A13058-A13058
• Main Authors: Wilkoff, Bruce L, Boriani, Giuseppe, Mittal, Suneet, Poole, Jeanne E, Kennergren, Charles, Corey, G Ralph, Love, John C, Augostini, Ralph, Faerestrand, Svein, Wiggins, Sherman S, Healey, Jeff S, Holbrook, Reece, Lande, Jeff D, Willey, Sarah A, Tarakji, Khaldoun G
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.140.suppl_1.13058

IntroductionCurrent understanding of the clinical and economic impact of CIED infection is based on retrospective analyses from medical records or administrative claims data. The WRAP-IT study offers a prospectively designed opportunity to evaluate the impact of CIED infection on mortality, quality of life (QOL), and health care utilization (HCU) in the US healthcare system.MethodsThis was a pre-specified, as-treated analysis which evaluated clinical outcomes related to CIED infectionsmortality, QOL, interruption in CIED therapy (n=70) and HCU (infection in US pts resolved prior to study exit, n=38). QOL was evaluated with EuroQOL-5D (EQ-5D) utilities at implant, infection diagnosis, and 1, 3, 6-months after diagnosis. Primary diagnosis codes, procedure codes and diagnosis related group assignments were imputed from study data. Payer costs were assigned using Medicare national payments, while hospital and patient costs were derived from similar hospital admissions in a separate administrative dataset. All currency reflects 2017 US dollars.ResultsMajor CIED infection was associated with increased all-cause mortality (12-month risk-adjusted HR 3.13, p