Design, synthesis, conjugation and reactivity of novel trans,trans-1,5-cyclooctadiene-derived bioorthogonal linkers

The tetrazine/trans-cyclooctene (TCO) inverse electron-demand Diels–Alder (IEDDA) reaction is the fastest bioorthogonal “click” ligation process reported to date. In this context, TCO reagents have found widespread applications; however, their availability and structural diversity is still somewhat...

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Bibliographic Details

Main Authors:	Beatrice Longo, Chiara Zanato, Monica Piras, Sergio Dall'Angelo, Albert D Windhorst, Danielle Vugts, Massimiliano Baldassarre, Matteo Zanda
Format:	Default Article
Published:	2020
Subjects:	Organic chemistry not elsewhere classified Organic Chemistry Medicinal and Biomolecular Chemistry Biochemistry and Cell Biology
Online Access:	https://hdl.handle.net/2134/12744740.v1
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