Systematic model-based dynamic optimization of a combined cooling and antisolvent multistage continuous crystallization process

A rigorous and systematic methodology was developed to optimize multistage combined cooling and antisolvent continuous MSMPR (mixed-suspension, mixed-product removal) crystallizers. The crystallization of aspirin (acetylsalicylic acid, ASA) in ethanol (solvent) and water (antisolvent) was used as a...

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Bibliographic Details
Main Authors: Jiaxu Liu, Brahim Benyahia
Format: Default Book chapter
Published: 2021
Subjects:
continuous crystallization
start-up
antisolvent
optimal seeding
dynamic optimization
Online Access:https://hdl.handle.net/2134/14995017.v1
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