The adaptability of the ion binding site by the Ag(I)/Cu(I) periplasmic chaperone SilF.

The periplasmic chaperone SilF has been identified as part of an Ag(I) detoxification system in Gram negative bacteria. Sil proteins also bind Cu(I), but with reported weaker affinity, therefore leading to the designation of a specific detoxification system for Ag(I). Using isothermal titration calo...

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Main Authors:	Ryan M Lithgo, Marko Hanževački, Gemma Harris, Jos JAG Kamps, Ellie Holden, Tiberiu-Marius Gianga, Justin LP Benesch, Christof M Jäger, Anna Croft, Rohannah Hussain, Jon L Hobman, Allen M Orville, Andrew Quigley, Stephen B Carr, David J Scott
Format:	Default Article
Published:	2023
Subjects:	Biological sciences Biomedical and clinical sciences Chemical sciences Biochemistry & Molecular Biology Silver ion binding Metal ion chaperone Thermodynamic QM-MM Structural biology
Online Access:	https://hdl.handle.net/2134/24372562.v1
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