Amyloid-β precursor protein processing and oxidative stress are altered in human iPSC-derived neuron and astrocyte co-cultures carrying presenillin-1 gene mutations following spontaneous differentiation

Introduction: Presenilin-1 (PSEN1) gene mutations are the most common cause of familial Alzheimer's disease (fAD) and are known to interfere with activity of the membrane imbedded γ-secretase complex. PSEN1 mutations have been shown to shift Amyloid-β precursor protein (AβPP) processing toward...

Full description

Bibliographic Details

Main Authors:	Richard J Elsworthy, Marianne C King, Alastair Grainger, Emily Fisher, James A Crowe, Sarah Alqattan, Adele Ludlam, Eric Hill, Sarah Aldred
Format:	Default Article
Published:	2021
Subjects:	Biochemistry and cell biology Neurosciences Psychology Cognitive and computational psychology Alzheimer's disease Amyloid-β Presenilin-1 ADAM10 iPSCs Oxidative stress
Online Access:	https://hdl.handle.net/2134/24807465.v1
Tags:	Add Tag No Tags, Be the first to tag this record!