A framework for systematic crystal shape tuning – case of Lovastatin's needle-shaped crystals

One of the most important challenges in the pharmaceutical industry is to produce crystals with desired size and shape distributions, to enhance the critical quality attributes of the drug product, such as efficacy, and to improve manufacturability during downstream processing, such as filtration, d...

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Bibliographic Details
Main Authors: Wei Li, Lauren E Hatcher, Chick C Wilson, Chris Rielly, Brahim Benyahia
Format: Default Article
Published: 2023
Subjects:
Chemical engineering
Environmental engineering
Maritime engineering
Resources engineering and extractive metallurgy
Applied mathematics
Direct nucleation control
Lovastatin
Batch crystallization
Wet milling
Shape modifier
Supersaturation control
Unseeded and seeded systems
Workflow
Aspect ratio
Online Access:https://hdl.handle.net/2134/24850185.v1
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