Sustainability and quality by digital design of integrated continuous pharmaceutical processes

The thesis addresses some of the key challenges in designing continuous pharmaceutical manufacturing processes, focusing on comparing different recycle scenarios around the filtrate stream in crystallisation, identifying critical process parameters from large sets of process parameters, using a sust...

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Bibliographic Details
Main Author: Tim Campbell
Format: Default Thesis
Published: 2025
Subjects:
Chemical engineering not elsewhere classified
Digital twins
Sustainability by design
Quality by Design (QbD)
Life cycle analysis
Quality by digital design
Integrated pharmaceutical manufacturing process
Continuous crystallisation
Analytical hierarchy process (AHP)
Recycle crystallisation
Continuous Ibuprofen Manufacture
Global sensitivity analysis (GSA)
Estimability analysis
Surrogate modelling
Quality risk management
Critical process parameters
Critical material attributes
Critical quality attributes
Pearsons correlation coefficient
Process parameter ranking
Online Access:https://dx.doi.org/10.26174/thesis.lboro.29333147.v1
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