Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease

One Sentence Summary: Quinazolines targeting lysyl tRNA synthase show partial efficacy in a mouse model of ChagasAccessible Summary: New drugs are required to treat Chagas disease, a deadly parasitic infection prevalent in Latin America. Here, Tulloch et al. investigate the mechanism of action of a...

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Bibliographic Details
Main Authors: Lindsay B Tulloch, Hugh Tawell, Annie E Taylor, Marta Lopes Lima, Alice Dawson, Sandra Carvalho, Richard J Wall, Victoriano Corpas-Lopez, Gourav Dey, Jack Duggan, Luma Godoy Magalhaes, Leah S Torrie, Laura Frame, David Robinson, Stephen Patterson, Michele Tinti, George Weaver, William J Robinson, Monica Cal, Marcel Kaiser, Pascal Mäser, Peter Sjö, Benjamin Perry, John M Kelly, Amanda Fortes Francisco, Avninder S Bhambra, Susan Wyllie
Format: Default Article
Published: 2025
Subjects:
Biological sciences
Biomedical and clinical sciences
Medical biotechnology
Biomedical engineering
Chagas disease
Latin America disease
Quinazoline compounds
Trypanosoma
Online Access:https://hdl.handle.net/2134/29625860.v1
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