Nucleophilic substitution of 1,3-diiodobicyclo[1.1.1]pentane: synthesis of bicyclo[1.1.1]pentylpyridinium, quinolinium, isoquinolinium, and pyrazolium salts

In this study, we describe the synthesis of bicyclo[1.1.1]pentane salts by the nucleophilic reaction of 1,3-diodobicyclo[1.1.1]pentane (DIBCP) with several classes of nucleophiles. The bicyclo[1.1.1]pentane fragments are established isosteres for tbutyl, alkynyl, and 1,4-diaryl structural units, who...

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Bibliographic Details

Main Authors:	Harvey J.C. Monroe, Dolapo Bello, Bradley J. Duff, Mark Elsegood, Kohei Watanabe, Gareth J. Pritchard, Marc Kimber
Format:	Default Article
Published:	2025
Subjects:	Medicinal and biomolecular chemistry Organic chemistry Anion Cations Infrared light Pyridines Salts
Online Access:	https://hdl.handle.net/2134/30075955.v1
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