Numerical modelling for coupled flow, transport, pharmacokinetic and pharmacodynamic of tablet-loaded hollow microneedle patch for transdermal drug delivery

In this study, we report the development of a numerical simulation framework for controlled transdermal de?livery of ibuprofen (IBU) using a tablet-loaded hollow microneedle (HMN) patch. The model integrates pressure?-driven, coupled laminar flow through the MN lumen and skin tissue, employing the B...

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Bibliographic Details

Main Authors:	Ravi Prakash, Rahul Nadda, Diganta Das, Ryan F Donnelly
Format:	Default Article
Published:	2025
Subjects:	Pharmacology and pharmaceutical sciences Hollow microneedles Finite element analysis Porous media Transdermal drug delivery Pharmocokinetics
Online Access:	https://hdl.handle.net/2134/30518489.v1
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