Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H2S in biological samples

H2S reversibly modifies low molecular weight (LMWSH) and protein (PrSH) thiols to form persulfides (RSS− ) and polysulfides (RS(S)nS − ) for antioxidant defence and regulation of activity. However, our understanding of the biological significance of these processes is hampered by our inability to qu...

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Bibliographic Details
Main Authors: Jan Lj Miljkovic, Nils Burger, Chak Shun Yu, Alexander H Harkiss, Stefan Warrington, Stuart T Caldwell, Scott A Jones, Jordan J Lee, Dunja Aksentijevic, Andrew M James, Thomas Krieg, Richard C Hartley, Michael P Murphy
Format: Default Article
Published: 2025
Subjects:
Hydrogen sulfide (H₂S)
Persulfidation
Persulfides
Polysulfides
LC–MS/MS
Thiol redox biology
Online Access:https://hdl.handle.net/2134/31296955.v1
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