Altered metabolic function induced by Aβ-oligomers and PSEN1 mutations in iPSC-derived astrocytes

Altered energy metabolism in Alzheimer's disease (AD) is a major pathological hallmark implicated in the early stages of the disease process. Astrocytes play a central role in brain homeostasis and are implicated in multiple neurodegenerative diseases. Although numerous studies have investigate...

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Bibliographic Details
Main Authors: Richard J. Elsworthy, Mattea J. Finelli, Sarah Aqattan, Connor Dunleavy, Marianne King, Adele Ludlam, Marta A. Tarczyluk, Sophie L. Allen, Sophie Prosser, Rui Chen, Sandra Martinez Jarquin, Dong H. Kim, James Brown, H. R. Parri, Sarah Aldred, Eric Hill
Format: Default Article
Published: 2024
Subjects:
Biochemistry and cell biology
Neurosciences
Neurology & Neurosurgery
Alzheimer's
Astrocytes
Gliosis
Inflammation
Metabolism
Stem cells
Online Access:https://hdl.handle.net/2134/31324102.v1
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