Incorporating primary human renal proximal tubule cells into a hollow fibre bioreactor in the development of an in vitro model for pharmaceutical research

Current in vitro cellular methods utilised in drug metabolism and pharmacokinetic (DMPK) studies during drug development do not provide the 3D structure and functions of organs found in vivo, such that resulting in vitro-in vivo extrapolation (IVIVE) may not always accurately reflect clinical outcom...

Full description

Saved in:
Bibliographic Details
Main Author: Maaria Ginai
Format: Default Thesis
Published: 2015
Subjects:
Chemical engineering not elsewhere classified
DMPK
Proximal tubule cells
Drug transporters
Polysulfone
Hollow fibre bioreactors
Bioartifical kidney device
In vitro cell model
Chemical Engineering not elsewhere classified
Online Access:https://hdl.handle.net/2134/20110
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items