End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation

A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug prod...

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Bibliographic Details

Main Authors:	Salvatore Mascia, Patrick L. Heider, Haitao Zhang, Richard Lakerveld, Brahim Benyahia, Paul I. Barton, Richard D. Braatz, Charles L. Cooney, James M.B. Evans, Timothy F. Jamison, Klavs F. Jensen, Allan S. Myerson, Bernhardt L. Trout
Format:	Default Article
Published:	2013
Subjects:	Chemical engineering not elsewhere classified Continuous processing Flow chemistry Lactones Protecting groups Synthetic methods Chemical Engineering not elsewhere classified
Online Access:	https://hdl.handle.net/2134/15287
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