Permeability enhancement for transdermal delivery of large molecule using low-frequency sonophoresis combined with microneedles

Transdermal drug delivery is limited by the high resistance of skin towards diffusion of high-molecular-weight drugs. This is mainly because of the fact that the outer layer of the skin, that is the stratum corneum, can prevent diffusion of molecules whose molecular weight is greater than 500 Da. So...

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Bibliographic Details
Main Authors: Tao Han, Diganta Das
Format: Default Article
Published: 2013
Subjects:
Chemical engineering not elsewhere classified
Transdermal drug delivery
Sonophoresis
Microneedles
Franz diffusion cell
Permeability
High molecular weight drug
HPLC
Skin
Ultrasound
Diffusion
Chemical Engineering not elsewhere classified
Online Access:https://hdl.handle.net/2134/14355
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