Experimental implementation of a Quality-by-Control (QbC) framework using a mechanistic PBM-based nonlinear model predictive control involving chord length distribution measurement for the batch cooling crystallization of L-ascorbic acid

L-ascorbic acid is synthetized in large industrial scale from glucose and marketed as an immune system strengthening agent and anti-oxidant ingredient. The overall yield of conversion of the precursor glucose to L-ascorbic acid is limited, therefore the crystallization is a critically important step...

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Bibliographic Details

Main Authors:	Botond Szilagyi, Akos Borsos, Kanjakha Pal, Zoltan Nagy
Format:	Default Article
Published:	2018
Subjects:	Chemical engineering not elsewhere classified Mechanical engineering not elsewhere classified Ascorbic acid DNC Population balances NMPC Quality-by-Control QbC Chemical Engineering not elsewhere classified Mechanical Engineering
Online Access:	https://hdl.handle.net/2134/36093
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