Agitation and aeration of stirred-bioreactors for the microcarrier culture of human mesenchymal stem cells and potential implications for large-scale bioprocess development

The impact of agitation rate and sparged aeration on BM-hMSC expansion in conventional stirred tank bioreactors was assessed. It was found that a decrease in impeller speed to below N JS caused sampling difficulties, clumping and an increase to ∼2 N JS decreased the growth rate though an intermediat...

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Bibliographic Details
Main Authors: Thomas R.J. Heathman, Alvin W. Nienow, Qasim A. Rafiq, Karen Coopman, Bo Kara, Christopher J. Hewitt
Format: Default Article
Published: 2018
Subjects:
Chemical engineering not elsewhere classified
Process control
Human mesenchymal stem cell
Microcarrier expansion
Harvest
Agitation
Aeration
Chemical Engineering not elsewhere classified
Online Access:https://hdl.handle.net/2134/33392
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