Using mathematical modelling to explore hypotheses about the role of bovine epithelium structure in foot-and-mouth disease virus-induced cell lysis

Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals. FMD virus (FMDV) shows a strong tropism for epithelial cells, and FMD is characterised by cell lysis and the development of vesicular lesions in certain epithelial tissues (for example, the tongue). By contrast, ot...

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Bibliographic Details
Main Authors: Kyriaki Giorgakoudi, Simon Gubbins, John Ward, Nicholas Juleff, Zhidong Zhang, David Schley
Format: Default Article
Published: 2015
Subjects:
Other mathematical sciences not elsewhere classified
Foot-and-mouth disease virus
Epithelium
Lysis
Cell death
Mathematical model
Partial differential equations
Parameter estimation
Sensitivity analysis
Mathematical Sciences not elsewhere classified
Online Access:https://hdl.handle.net/2134/19384
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https://hdl.handle.net/2134/19384

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