Design and synthesis of an RGD peptidomimetic-paclitaxel conjugate targeting αvβ3 integrin for tumour-directed drug delivery

A 1,2,3-triazole-based RGD peptidomimetic having nanomolar affinity for α v β 3 integrin was conjugated to the potent antimitotic paclitaxel via an oxime heterobifunctional linker. The resulting construct maintained nanomolar binding concentration to α v β 3 integrin and showed 11-fold selectivity i...

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Bibliographic Details

Main Authors:	Monica Piras, Alexandra Andriu, Andrea Testa, Paul Wienecke, Ian N. Fleming, Matteo Zanda
Format:	Default Article
Published:	2017
Subjects:	Organic chemistry not elsewhere classified Other chemical sciences not elsewhere classified RGD Peptidomimetic Integrin Paclitaxel Click Cytotoxicity Cancer Chemical Sciences not elsewhere classified Organic Chemistry
Online Access:	https://hdl.handle.net/2134/36582
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