Novel fluorinated benzimidazole-based scaffolds and their anticancer activity in vitro

A small library of twelve, structurally diverse, fluoroaryl benzimidazoles was prepared using a simple synthetic strategy employing SNAr reactions. This allowed rapid assembly of heterocyclic structures containing linked and tethered fluoroaryl benzimidazoles. X-ray crystal structures of seven compo...

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Bibliographic Details

Main Authors:	Avninder S. Bhambra, Mark Edgar, Mark Elsegood, Lynne Horsburgh, Vladimir Krystof, Paul D. Lucas, Mariam Mojally, Simon J. Teat, Thomas G. Warwick, George Weaver, Fatemeh Zeinali
Format:	Default Article
Published:	2016
Subjects:	Inorganic chemistry not elsewhere classified Organic chemistry not elsewhere classified Other chemical sciences not elsewhere classified Anticancer activity Benzimidazole C-F activation Fluorinated drug scaffolds SNAr substitution Chemical Sciences not elsewhere classified Inorganic Chemistry Organic Chemistry
Online Access:	https://hdl.handle.net/2134/21901
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