Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters

© 2016 Elsevier Ltd With the aim of identifying a fluorinated bile acid derivative that could be used as [18F]-labeled Positron Emission Tomography (PET) tracer for imaging the in vivo functioning of liver transporter proteins, and particularly of OATP1B1, three fluorinated bile acid triazole deriva...

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Bibliographic Details
Main Authors: Andrea Testa, Sergio Dall'Angelo, Marco Mingarelli, Andrea Augello, Lutz Schweiger, Andrew Welch, Charles S. Elmore, Pradeep Sharma, Matteo Zanda
Format: Default Article
Published: 2017
Subjects:
Organic chemistry not elsewhere classified
Other chemical sciences not elsewhere classified
Fluorine
Bile acids
Liver transporters
PET imaging
Tritium
Preclinical study
Click chemistry
Clearance
Chemical Sciences not elsewhere classified
Organic Chemistry
Online Access:https://hdl.handle.net/2134/36724
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https://hdl.handle.net/2134/36724

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