Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

Mapping the landscape of possible macromolecular polymer sequences to their fitness in performing biological functions is a challenge across the biosciences. A paradigm is the case of aptamers, nucleic acids that can be selected to bind particular target molecules. We have characterized the sequence...

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Bibliographic Details

Main Authors:	Christopher G. Knight, Mark Platt, William Rowe, David C. Wedge, Farid Khan, Philip J.R. Day, Andy McShea, Joshua Knowles, Douglas B. Kell
Format:	Default Article
Published:	2009
Subjects:	Other chemical sciences not elsewhere classified untagged Chemical Sciences not elsewhere classified
Online Access:	https://hdl.handle.net/2134/11316
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