Determination of free desmosine and isodesmosine as urinary biomarkers of lung disorder by ultra performance liquid chromatography-ion mobility-mass spectrometry

The elastin degradation products, desmosine (DES) and isodesmosine (IDES) are highly stable, cross-linking amino-acids that are unique to mature elastin. The excretion of DES/IDES in urine, in the free form and with associated peptide fragments, provides an indicator of lung damage in chronic obstru...

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Bibliographic Details
Main Authors: Neil A. Devenport, Jim Reynolds, Ved Parkash, Jason Cook, Daniel J. Weston, Colin Creaser
Format: Default Article
Published: 2011
Subjects:
Other chemical sciences not elsewhere classified
Ion mobility-mass spectrometry
Urinary analysis
COPD
Desmosine
Isodesmosine
Chemical Sciences not elsewhere classified
Online Access:https://hdl.handle.net/2134/8992
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https://hdl.handle.net/2134/8992

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