Catalytic asymmetric crotylation of aldehydes: application in total synthesis of (−)‐elisabethadione

A new, highly efficient Lewis base catalyst for a practical enantio- and diastereoselective crotylation of unsaturated aldehydes with E- and Z-crotyltrichlorosilanes has been developed. The method was employed as a key step in a novel asymmetric synthesis of bioactive serrulatane diterpene (À)-elisa...

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Bibliographic Details
Main Authors: Paul O'Hora, Celia A. Incerti-Pradillos, Mikhail A. Kabeshov, Sergei A. Shipilovskikh, Aleksandr E. Rubtsov, Mark Elsegood, Andrei Malkov
Format: Default Article
Published: 2015
Subjects:
Other chemical sciences not elsewhere classified
Allylation
Asymmetric catalysis
Rearrangement
Stereoselectivity
Total synthesis
Chemical Sciences not elsewhere classified
Online Access:https://hdl.handle.net/2134/16845
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