Asymmetric total synthesis of (-)-erogorgiaene and its C11 epimer and investigation of their antimycobacterial activity

A short, nine-step, highly enantioselective synthesis of (−)-erogorgiaene and its C-11 epimer is reported. The key stereochemistry controlling steps involve catalytic asymmetric crotylation, anionic oxy-Cope rearrangement and cationic cyclisation. (−)-Erogorgiaene exhibited promising antitubercular...

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Main Authors:	Celia A. Incerti-Pradillos, Mikhail A. Kabeshov, Paul O'Hora, Sergei A. Shipilovskikh, Aleksandr E. Rubtsov, Vera A. Drobkova, Svetlana Yu Balandina, Andrei Malkov
Format:	Default Article
Published:	2016
Subjects:	Other chemical sciences not elsewhere classified Allylation Asymmetric catalysis Rearrangement Stereoselectivity Total synthesis Chemical Sciences not elsewhere classified
Online Access:	https://hdl.handle.net/2134/22370
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