The trifluoromethyl group as a bioisosteric replacement of the aliphatic nitro group in CB1 receptor positive allosteric modulators

The first generation of CB1 positive allosteric modulators (PAMs; e.g., ZCZ011) featured a 3-indolyl-nitromethane structure. Although a small number of drugs include the nitro group, it is generally not regarded as being “drug-like”, and this is particularly true for aliphatic nitro groups. There ar...

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Bibliographic Details

Main Authors:	Chih-Chung Tseng, Gemma Baillie, Giulia Donvito, Mohammed Mustafa, Sophie Juola, Chiara Zanato, Chiara Massarenti, Sergio Dall'Angelo, William T. Harrison, Aron H. Lichtman, Ruth Ross, Matteo Zanda, Iain R. Greig
Format:	Default Article
Published:	2019
Subjects:	Organic chemistry not elsewhere classified Other chemical sciences not elsewhere classified untagged Chemical Sciences not elsewhere classified Organic Chemistry
Online Access:	https://hdl.handle.net/2134/37715
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