Direct detection of a sulfonate ester genotoxic impurity by atmospheric-pressure thermal desorption−extractive electrospray−mass spectrometry

A direct, ambient ionization method has been developed using atmospheric pressure thermal desorption−extractive electrospray−mass spectrometry (AP/TD-EESI-MS) for the detection of the genotoxic impurity (GTI) methyl p-toluenesulfonate (MTS) in a surrogate pharmaceutical matrix. A custom-made thermal...

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Bibliographic Details
Main Authors: Neil A. Devenport, Laura C. Sealey, Faisal H. Alruways, Daniel J. Weston, Jim Reynolds, Colin Creaser
Format: Default Article
Published: 2013
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Online Access:https://hdl.handle.net/2134/12728
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