Mannich reactions of alkynes: mechanistic insights and the role of sub-stoichiometric amounts of alkynylcopper(I) compounds in the catalytic cycle

Yellow polymeric alkynylcopper(I) compounds observed in the three-component Mannich reactions of alkynes, secondary amines and aldehydes are shown to be pre-catalysts that give rise to catalytic copper(I) alkyne complexes by interaction with secondary amines (see scheme). Interaction of these comple...

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Bibliographic Details
Main Authors: Benjamin Buckley, Amna N. Khan, Harry Heaney
Format: Default Article
Published: 2012
Subjects:
Other chemical sciences not elsewhere classified
Alkynes
Mannich bases
Mechanistic studies
Multicomponent reactions
Propargylamines
Chemical Sciences not elsewhere classified
Online Access:https://hdl.handle.net/2134/16568
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